Clinical Practice Research Datalink: A UK Resource for Cancer Epidemiology Research

Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E156 Bethesda, MD 20892, UNITED STATES DESCRIPTION The U.S. Department of Health and Human Services (DHHS), National Institutes of Health (NIH), National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), intends to procure a license to access databases of medical records on a sole source basis from the UK Clinical Practice Research Datalink (CPRD). This procurement is being conducted using commercial item procedures pursuant to FAR Part 12 and FAR Part 13, specifically FAR Subpart13.106-1(b)(1)(i) allowing the Contracting Officer (CO) to solicit from one source. Only one award will be made as a result of this solicitation. This will be awarded as a non-severable Firm-fixed price type contract with one base and two option periods. It has been determined there are no opportunities to acquire green products or services for this procurement. BACKGROUND The UK Clinical Practice Research Datalink (CPRD) is the worlds largest longitudinal database of primary care medical records containing 13 million individuals (5 million of them are active patients), contributing 1.5 billion clinical records, and more than 1 billion therapy records. The age, gender, and death rate distribution of the CPRD population is similar to that of the UK general population, minimizing selection bias and maximizing results generalizability. In contrast to other large registry databases available to DCEG investigators, the collected information in CPRD was not intended for medical billing purposes but for detailed clinical epidemiological investigation. Specifically, CPRD data contain clinical diagnoses, patient lifestyle factors, results of diagnostic testing, specialist referrals, and prescription information; additional information can be collected through physician questionnaires. The data is currently linkable to other population-based registries, including the National Cancer Intelligence Network, the UK Hospital Episode Statistics, Death Registration, and Patient and Practice-based Deprivation Data. Academic institutions in the UK and across the world, in addition to regulatory agencies including the FDA have used CPRD for their research. Studies using CRPD have resulted in more than 1000 peer-reviewed publications between 1988 and the end of 2013 with a continuous rising trend in the last 4 years. Since 2015, the NCI has executed several contractual agreements with CPRD with the latest being (HHSN261201700038P). This allowed investigators in the Division of Cancer Epidemiology and Genetics access to this rich data resource. Currently more than 10 investigators in DCEG are using this resource. OBJECTIVE The purpose of the current procurement is to pay for a license to access the following datasets: UK CPRD primary care databases (Gold and Aurum) NHS digital datasets (Hospital Episode Statistics (HES) Admitted Patient Care (HES APC), HES Outpatient, and Death Registration data from the Office for National Statistics (ONS) Small area level dataset (Index of Multiple Deprivation; IMD). And pay for study-based access to the PHE cancer registry database and other linkages that are not covered by a CPRD license, as needed. SCOPE CPRD will provide 12 months with 2 option periods of unlimited access to the datasets identified above and needed services for linking datasets to the CPRD Primary Care database on an individual patient level; and to PHE cancer registry data and other linkages per study need. CONTRACT REQUIREMENTS AND PERSONNEL QUALIFICATIONS The Contractor shall perform the following tasks: Provide NCI with a full access license to the databases identified above Provide necessary service for linking different datasets to datasets to the CPRD Primary Care database on an individual patient level. Provide access to other linkage databases per study need. Provide necessary training and data-related documentations to NCI, as needed throughout the contract period. Provide epidemiological support for data users. Provide day-to-day troubleshooting for technical problems related to data access. Facilitate linkage to other UK resources. TYPE OF ORDER This is a non-severable Firm Fixed Price purchase order. PERIOD OF PERFORMANCE The period of performance shall be one 12 month base period with two 12 month option periods. Base Period: August 21, 2020 through August 20, 2021 Option Period One: August 21, 2021 through August 20, 2022 Option Period Two: August 21, 2022 through August 20, 2023 PLACE OF PERFORMANCE Onsite services shall be performed at the following location: Division of Cancer Epidemiology and Genetics National Cancer Institute 9609 Medical Center Drive Rockville, MD 20850 REPORT(S)/DELIVERABLES Access to the databases identified above and services required for their use throughout the contract period. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 12:00 PM EST on August 10, 2020. All responses and questions must be emailed to Jolomi Omatete, Contracting Officer via electronic mail at Jolomi. [email protected]. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered and have valid certification in the System for Award Management (SAM) through sam.gov. Reference: 75N91020Q00121 on all correspondence.