Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office is soliciting innovative research proposals for the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) program. This initiative seeks to demonstrate proof-of-concept for novel mechanisms designed to write and erase epigenetic base modifications in DNA. These research efforts aim to develop technologies capable of modifying the epigenome in vitro, providing new methods for controlling DNA-protein interactions and investigating the functions of rare or novel epigenetic modifications.

This special notice, identified by solicitation number DARPA-SN-26-67, falls under NAICS code 541714 for Research and Development in Biotechnology (except Nanobiotechnology) and PSC AC11 for National Defense R&D Services; Department of Defense - Military; Basic Research. Amendment 01 was issued on May 18, 2026, to clarify submission instructions and deadlines. The primary point of contact for this requirement is Dr. Aric Lu, and the notice includes two PDF attachments containing the original solicitation and the subsequent amendment.

Responses to this research opportunity are due by June 24, 2026. The procurement is managed by the Departmental Offices and is classified as basic research focused on the engineering of nucleic acids. All technical objectives and performance requirements are centered on the advancement of epigenetic chemistry and biotechnology capabilities.