Proactive Health Office (PHO) Mission Office Innovative Solutions Opening (ISO)

The Advanced Research Projects Agency for Health (ARPA-H), within the National Institutes of Health, is seeking innovative solutions to improve the healthspan and health outcomes of Americans. This initiative focuses on enhancing proactive health measures prior to the onset of disease or diminished quality of life. The Proactive Health Office (PHO) identifies three primary areas of interest: increasing population-level access to disease prevention and wellness behaviors, developing novel early-detection methods and prophylactic interventions, and implementing system-level innovations to deliver proactive health services effectively.

Solicitation ARPA-H-SOL-24-106 is categorized under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AN13 for Health R&D Services; Health Care Services; Experimental Development. The performance location is within the United States. Amendment 4, effective as of June 10, 2026, updated the administrative and national policy requirements, renamed the submission portal to the ARPA-H Solutions Site, and revised research security disclosure language. While 18 attachments are associated with this notice, including a bundle of updated forms and submission links, entities that previously submitted both a solution summary and a proposal are not required to take further action.

The response deadline for this solicitation is March 6, 2029. Interested parties must submit solution summaries, questions, and full proposals through the designated ARPA-H Solutions Site. Any proposals submitted following the issuance of Amendment 4 must comply with the revised administrative and security disclosure guidelines. Points of contact are managed through the agency's online submission and inquiry portals.